Nanoparticles in Liquids

Morphious Nano-Insight Nanoparticles Analyzer

Morphious Nano-Insight Nanoparticles Analyzer
The Morphious Nano-Insight is designed to visualize and analyze particles in liquids that relates the rate of Brownian motion of particles to the size distribution. The technique is using so called Nano particle Tracking Analysis (NTA) where images of nano particles are generated through a laser scattering device (Nano-Insight) in conjunction with a so called Ultra Microscope and NTA software.
Nanoparticles in Liquids analyzer
Principles of Morphious Nano-Insight

Tracking Nano Particles

Nanoparticles in Liquids analyzerWith the Nano-Insight laser scattering module, nano particles in liquids can be visualized through the  Top-eye Ultra Microscope. The particles, depending on what laser used, are manifested as Fuzzy dots in a matrix. Dots which are moving in accordance with its respective  Brownian motion. There are different particles with Brownian motion. Small particles are less influenced by adjacent particles as the large particles. Hence larger particles have large Fuzzy appearance in Ultra microscope image. NTA can tract the respective paths of the particles.

Nano-Insight Module

Nanoparticles in Liquids analyzerThis module is designed such that it can be mounted on the baseplate of our Ultra Microscope, the Top-eye nano. The module can be controlled through our Mishell Software. The software controls the Nano-Insight module as well as the camera. The Nano-Insight module is equipped with either one or more lasers depending on the application. The laser is arranged in a particular way. The diagram of the Nano-insight is shown on the left picture. The smaller particles move faster than the bigger ones. We track each particle simultaneously with the camera.

Top-Eye Ultra Microsope

The Top-eye Ultra Microscope visualizes the scattered light into fuzzy dots. With appropriate time resolved tracking the Fuzzy clouds can be assigned and related with the respective particle sizes. The images of the Brownian motion of the particles are unique. The example is given below. Each Fuzzy dots represent individual particles.

Nanoparticles in Liquids analyzer

NTA Software

The picture above shows a typical image of a NTA analysis. The scattered laser light is captured into fuzzy points which are tracked in function of time. We follow each individual Fuzzy point. As the method is following each particle individual the resulting technology is high resolution. As we know the volume related with the image we are looking at, we can determine with extreme accuracy the concentration of various particles. The technology offers a wealth of possible applications. For example it is also possible to use a fluorescent laser. In this way one can target particles in a complex matrix. The benefit if this technology is that the user can visually inspect and validate all possible applications by looking at the respective images.

Nanoparticles in Liquids analyzer

MiNan is a module within Mishell® - our extended image analysis software package considered to be the most sophisticated software of its kind available in the market. MiNan is a subroutine which allows full characterization of Morphious Nanoparticles Analysis.

Nanoparticles in Liquids analyzerMiNan is the software which comes with a Morphious Nano system and is developed to visualize and measure nanoparticles size and shape (morphometry) and concentration. Each particle is individually but simultaneously analysed by direct observations of diffusion. This particle-by-particle methodology produces high resolution results for particle size distribution and concentration while visual validation gives users extra confidence in the data. As well as particle size and concentration, protein aggregation and viscosity can all be analysed while a fluorescence mode provides detection of labelled particles


Nanoparticles in Liquids analyzer Nanoparticles in Liquids analyzer

Applications with Morphious Nano-Insight

In Pharmaceutical or composite industry to develop drugs
For viral screening
For developing Nano-biomarkers or toxicology screening
For studying kinetic models in protein aggregation
For studying diseases through Extracellular vesicle characterization
For characterisation of building blocks in Nano composite material development

Key Benefit of Morphious Nano-Insight

High throughput characterisation of many particles at the same time
Real time visual display of particles allowing user to assess experiments without extra complexity
Convenient and easy to use software allowing user to set up any experiments through macros
Add on accessories like high throughput auto samplers, pumps or heating & cooling
Adaptive modular systems to build any complex application allowing operation to be easy and comfortable
Utterly efficient and low cost of ownership
The system offers high resolution particle size characterisation to investigate complex multi dispersive matrixes
Choice of laser wavelength
Adaptive fluorescence analysis by adding a motorized wheel with filters

Key Specifications

Size 10 nm - 2000 nm*
Concentration 106 - 109 particles per mL
Fluorescence detection

System Specifications

Temperature Range 15-40 °C
Power Supply 230V AC/115V AC, 50/60 Hz
Camera  USB 3 CMOS resolution: 1936 x 1216, 161 f/s, Pixel size 5.86 µm: Color calibration module.
Power consumption 18W
Laser wavelengths 405 nm (Violet), 488 nm (Blue), 532 nm (Green), 642 nm (Red)
Size range From 10 nm till 2000 nm (depending on material)
Focus Computer controlled motorized focus
PC SDD SanDisk Ultra II SDSSDHII-120G-G25 HDD Western Digital Blue WD10EZEX 1 TB | Motherboard  Gigabyte GA-Z97X-UD3H|RAM  Kingston HyperX Fury Black |HX318C10FBK2/16 16 GB DDR3-RAM
Processor Intel® Core™ i7 i7-4790K Quad Core 4 x 4.0 GHz
Graphics Card PNY VCQK2200-PB 4 GB
Power supply Coolermaster G750M 750 W
PC box Cooler Master Black
Software Windows® & (or higher). Powered by Mishell®
Mishell is a registered trademark of Microptik BV
Windows is a registered trademark of Microsoft corporation
MiNan sophisticated routine runs under Mishell to fully characterize nano particles acquired with Morphious Nano
Dimensions (LxWxH) 20 x 18 x 30 cm
Weight 10.5 kg